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Neuropeptide Y and epilepsy: recent progress, prospects and controversies
1Epilepsy Research Laboratory, Department of Neurological Surgery, University of California, 513 Parnassus Avenue, San Francisco, CA 94143, USA. baraban@itsa.ucsf.edu
Neuropeptides
|September 1, 2004
Abstract:
Neuropeptide Y (NPY), a 36 amino-acid member of the pancreatic polypeptide family, has received considerable attention in recent years as an endogenous modulator of epileptic activity. Prominently expressed in brain regions involved in seizure generation and propagation, NPY can exert powerful effects on synaptic transmission. Here, we discuss the anti-epileptic actions of NPY and receptor subtypes responsible.