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Updated: Aug 22, 2026

Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin
Published on: May 6, 2018
Tumor necrosis factor-alpha blocking agent as a treatment for nephrotic syndrome
David Raveh1, Ovadia Shemesh, Yaakov Jack Ashkenazi
1Division of Internal Medicine, Shaare Zedek Medical Center, Jerusalem, Israel. ravehmed@hotmail.com
Abstract:
We report a 13-year-old boy with refractory nephrotic syndrome (minimal change with mesangial proliferation) who failed the standard treatment protocols. There was some temporary response to large steroid doses, but even the Mendoza protocol could not induce remission. We show suppression of the proteinuria with Infliximab (Remicade) with tapering of steroids. Serial serum levels of tumor necrosis factor (TNF)-alpha are shown and discussed. We suggest studying the TNF-alpha blocking agents as optional treatment for nephrotic syndrome.
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