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Updated: Aug 22, 2026

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions
Published on: December 1, 2020
Predicting plasma protein binding of drugs--revisited
Nicole A Kratochwil1, Walter Huber, Francis Müller
1Department of Discovery Chemistry, F Hoffmann-La Roche, CH-4070 Basel, Switzerland. nicole_a.kratochwil@roche.com
Abstract:
Plasma protein binding of drugs has been studied for almost 100 years, but despite the accumulation of large amounts of data, the accurate prediction of this ADME parameter continues to be problematic. This review outlines recent efforts on the development of prediction tools for plasma protein binding of drugs, specifically human serum albumin, in the context of its relevance and its influencing factors. The issue of why it is difficult to achieve prediction of sufficient quality for a diverse dataset will also be considered.
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