Flow cytometric DNA analysis of oral squamous cell carcinoma in Iraqi patients
B T Garib1, S Al-Ani, N Al-Alwan
1Department of Oral Pathology, College of Dentistry, University of Baghdad, Baghdad, Iraq.
Abstract:
We studied the DNA content, DNA index and cell cycle parameters that are reliable markers for assessing the proliferative activity and aggressiveness of malignancies. Cytometric DNA analysis was performed on formalin-fixed paraffin embedded sections from 36 Iraqi patients with oral squamous cell carcinoma. The results showed that 20 of 36 cases (55.5%) were diploid, while 15 cases (41.7%) were aneuploid. Significantly higher S-phase fractions and higher DNA indices characterized aneuploid tumours. Nuclear DNA analysis as part of the evaluation of oral squamous cell carcinoma will influence the selection of appropriate treatment strategies.
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