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Nanosizing drug particles in supercritical fluid processing.

Pankaj Pathak1, Mohammed J Meziani, Tarang Desai

  • 1Department of Chemistry, Howard L. Hunter Chemistry Laboratory, Clemson University, Clemson, SC 29634-0973, USA.

Journal of the American Chemical Society
|September 2, 2004
PubMed
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The rapid expansion of a supercritical solution into a liquid solvent (RESOLV) process effectively created nanoscale Ibuprofen and Naproxen particles. These drug nanoparticles were stabilized in aqueous solutions, preventing agglomeration and precipitation.

Area of Science:

  • Pharmaceutical Technology
  • Materials Science
  • Chemical Engineering

Background:

  • Water-insoluble drugs present formulation challenges due to poor bioavailability.
  • Nanosizing drug particles can enhance dissolution rates and therapeutic efficacy.
  • Supercritical fluid technologies offer novel approaches for particle engineering.

Purpose of the Study:

  • To apply the RESOLV technique for the nanosizing of water-insoluble anti-inflammatory drugs.
  • To investigate the production of Ibuprofen and Naproxen nanoparticles using CO2-based supercritical systems.
  • To evaluate the stabilization of resulting drug nanoparticles in aqueous suspensions.

Main Methods:

  • Utilized the Rapid Expansion of a Supercritical Solution into a Liquid Solvent (RESOLV) process.

Related Experiment Videos

  • Employed carbon dioxide (CO2) and CO2-cosolvent systems for drug processing.
  • Incorporated polymeric and oligomeric agents for nanoparticle stabilization.

    • Main Results:

    • Successfully produced exclusively nanoscale (less than 100 nm) Ibuprofen and Naproxen particles.
    • Generated stable aqueous suspensions of drug nanoparticles.
    • Demonstrated the efficacy of RESOLV in creating sub-100 nm drug particles.

    Conclusions:

    • The RESOLV technique is effective for the nanosizing of water-insoluble drugs like Ibuprofen and Naproxen.
    • Supercritical fluid processing via RESOLV yields stable, nanoscale drug particles.
    • Stabilization agents are crucial for maintaining nanoparticle integrity in aqueous media.