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Ghrelin: update on a novel hormonal system.

M Korbonits1, A B Grossman

  • 1Department of Endocrinology, St Bartholomew's Hospital, London EC1A 7BE, UK. m.korbonits@qmul.ac.uk

European Journal of Endocrinology
|September 2, 2004
PubMed
Summary

Ghrelin, a stomach-secreted hormone, influences growth hormone, appetite, and metabolism. Further research into manipulating the ghrelin system could impact body weight and growth.

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Area of Science:

  • Endocrinology
  • Metabolic research
  • Physiology

Background:

  • Ghrelin is a peptide hormone produced in the stomach and other tissues.
  • It exerts both endocrine and paracrine effects throughout the body.
  • Ghrelin plays a role in various physiological processes.

Purpose of the Study:

  • To review the multifaceted roles of ghrelin.
  • To highlight ghrelin's influence on hormone secretion, appetite, metabolism, cardiovascular function, and cell proliferation.
  • To underscore the potential of ghrelin system manipulation for therapeutic applications.

Main Methods:

  • Literature review of ghrelin's physiological effects.
  • Analysis of ghrelin's impact on endocrine axes, appetite regulation, carbohydrate metabolism, cardiac function, and cell growth.
  • Exploration of potential therapeutic strategies targeting the ghrelin system.

Main Results:

  • Ghrelin stimulates growth hormone (GH), prolactin, and ACTH secretion.
  • It increases appetite and has diabetogenic effects on carbohydrate metabolism.
  • Ghrelin also exhibits positive inotropic cardiac effects, promotes vasodilation, and influences cell proliferation.

Conclusions:

  • Ghrelin is a key regulator of appetite, metabolism, and endocrine function.
  • Its diverse actions suggest significant potential for therapeutic intervention.
  • Chronic manipulation of the ghrelin system offers an exciting avenue for exploring treatments for conditions related to body weight, growth, and appetite.

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