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[Effect of Zhenju Jiangya Tablet on the endothelial function of hyperlipidemic rabbits]
Xu-Min Hou1, Huan-Chun Ni, Xin-Ping Luo
1Department of Cardiology, Huashan Hospital, Fudan University, Shanghai 200040, China.
Objective:
To study the effect of Zhenju Jiangya Tablet (ZJ) on the injured endothelial cells and endothelium-dependent relaxation function of hyperlipidemia rabbits.
Methods:
Male New Zealand rabbits were randomized into four groups: control group, hyperlipidemia group, ZJ group and sivastatin group. The endothelium-dependent relaxation function was evaluated by APV using intravascular Doppler, and the morphology of endothelial cells was detected by light microscopy and electron microscopy, and nitric oxide synthase was evaluated.
Results:
ZJ reduced the lesions of hyperlipidemia vessels, and the APV after Ach injection of each group was (1.14+/-0.26), (1.74+/-0.59), (1.22+/-0.37) and (1.17+/-0.41) respectively. The eNOS of each group was (4.21+/-0.37), (1.43+/-0.88), (3.95+/-0.67) and (4.08+/-0.46) nmol x min(-1) x g(-1) respectively.
Conclusion:
ZJ can improve the abnormality of endothelial cells and endothelium-dependent relaxation function of hyperlipidemia.
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