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[Correlation between TXB2, 6-Keto-PGF1alpha and liver metastasis in rats model with blood stasis]
Zhen Chen1, Lu-Ming Liu, Yi-Bei He
1Department of Traditional Chinese Medicine, Cancer Hospital, Fudan University, Shanghai 200032, China. chenzhen100@sohu.com
Objective:
To observe the correlation between serum level of TXB2, 6-Keto-PGF1alpha and liver metastasis.
Methods:
The metastatic model was made by injection of W256 carcinosarcoma. Rats were randomly divided into two groups: rats with blood stasis group and control group. Rats in control group were given normal saline via abdominal cavity once a day. Rats in blood stasis group were injected adrenalin in the fourteenth day. Tumor size and liver metastasis were observed. Serum TXB2 and 6-Keto-PGF1alpha were tested by radioimmunoassay.
Results:
Tumor size in rats with blood stasis was significantly smaller than that of the control group (P<0.01). Occurrence of liver metastasis in rats with blood stasis was significantly lower than that of the control group (P<0.01). The values of 6-Keto-PGF1alpha, TXB2, and TXB2/6-Keto-PGF1alpha were higher in the group with blood stasis.
Conclusion:
In the status of blood stasis, W256 carcinosarcoma grows slowly, and liver metastasis increases insignificantly, with the elevations of 6-Keto-PGF1alpha, TXB2 and TXB2/6-Keto-PGF1alpha.
