Related Experiment Video
Updated: Dec 31, 2025
Testing Cancer Immunotherapeutics in a Humanized Mouse Model Bearing Human Tumors
Published on: December 16, 2022
[Pingfei Mixture's two-way adjustment to cell proliferation in mice with tumor]
Shi-Jie Zhu1, Pei-Wen Li, Li-Qun Jia
1Tumor Department of Traditional Chinese Medicine, China-Japan Friendship Hospital, Beijing 100029, China. zhu.s.j@263.net
Objective:
To study the antineoplastic mechanism of Pingfei Mixture.
Methods:
Thirty C57BL mice bearing Lewis pulmonary carcinoma were randomly divided into 3 groups: saline control group, Pingfei Mixture group and cisplatin group. Fifteen days later, tumor tissues and spleens were taken out and made into unicellular suspension. Argyrophil staining was taken to carcinoma cells and cultured T cells. KL-2 style cell image analysis system was used to analyze the rate between AgNORs and nuclear region (I.S).
Results:
There were dense brownish-black granules in tumor cell nuclear of saline control group. The brownish-black granules of Pingfei Mixture group and cisplatin group were less than those of saline control group. The differences of T cell I.S in these three groups were significant. The I.S of Pingfei Mixture was higher than that of the other groups, and the I.S of the cisplatin group was the lowest.
Conclusion:
Pingfei Mixture can inhibit tumor cell proliferation, although the effect is inferior to cisplatin. Pingfei Mixture can also promote T cell proliferation and its effect was superior to cisplatin.
