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Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats
Published on: April 7, 2023
[Effect of Sophoricoside on histomorphology of bone in ovariectomized rats]
Ning Du1, Yong Xu, Wei-Zhen Chen
1Department of Orthopaedics and Traumatology, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China. duning@vip.163.com
Objective:
To evaluate the potential preventive effect of Sophoricoside on bone loss in ovariectomized rats.
Methods:
Female SD rats (n=50, 6 months old) were either sham-operated (SHAM group, n=10) or ovariectomized (n=40). Three days after operation, ovariectomized rats were randomly assigned to groups as follows: 10 received Sophoricoside 4 mg.kg(-1).d(-1) (SL group), 10 received Sophoricoside 8 mg.kg(-1).d(-1) (SM group), 10 received Sophoricoside 16 mg.kg(-1).d(-1) (SH group) and 10 were untreated (OVX group). After Sophoricoside were given orally for one month, the histomorphometric parameters in the secondary spongiosa of proximal tibia and lumbar vertebrae were examined.
Results:
Compared with OVX group, SM and SH two kinds of treatment caused 15.28% and 22.81% increment in percent trabecular area (BV/TV, %) in the secondary spongiosa of proximal tibia, 14.23% and 21.2% increment in lumbar vertebrae. Accordingly in these two groups, there was a significant decrease in trabecular separation (FLAW, microm), but increment in trabecular width (Tb. Th, microm) and conjunction points (JOINT). But in SL group, the preventive effect was not observed.
Conclusion:
Sophoricoside can be efficient in preventing ovariectomy-induced bone loss in rats.
