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Updated: May 6, 2026
09:34
Isolation of Murine Valve Endothelial Cells
Published on: August 21, 2014
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Sculpting heart valves with NFATc and VEGF
Diether Lambrechts1, Peter Carmeliet
1Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Leuven, Belgium.
Cell
|September 2, 2004
Abstract:
Heart valves are of vital importance for our moment-to-moment existence, but how they form remains a mystery. In this issue of Cell, Chang et al. reveal a novel role for calcineurin, NFATs, and VEGF in valve formation. Dynamic changes in NFAT/VEGF expression in regional myocardial and endocardial fields and developmental windows orchestrate this complex process.
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