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Related Experiment Videos

Age at onset and cognitive functioning in schizophrenia.

Annamari Tuulio-Henriksson1, Timo Partonen, Jaana Suvisaari

  • 1National Public Health Institute, Department of Mental Health and Alcohol Research, Mannerheimintie 166, 00300 Helsinki, Finland. annamari.tuulio-henriksson@ktl.fi

The British Journal of Psychiatry : the Journal of Mental Science
|September 2, 2004
PubMed
Summary

Earlier onset of schizophrenia is linked to worse verbal learning and memory. These cognitive functions are crucial for neuropsychological evaluation and treatment in early-onset schizophrenia patients.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Cognitive Psychology

Background:

  • Cognitive impairments are prevalent in schizophrenia.
  • The severity of cognitive deficits may correlate with the age of schizophrenia onset.

Purpose of the Study:

  • To investigate the relationship between age at schizophrenia onset and cognitive functioning.
  • Utilized the California Verbal Learning Test, Wechsler Memory Scale-Revised, and Wechsler Adult Intelligence Scale-Revised.

Main Methods:

  • Examined 237 individuals with schizophrenia from a population-based sample.
  • Employed linear mixed-effects models with family as a random effect.
  • Included age, gender, illness chronicity, and family history as fixed effects.

Main Results:

Related Experiment Videos

  • Earlier age at onset was associated with impaired verbal learning and memory.
  • No significant association was found between age at onset and working memory or IQ.

Conclusions:

  • Verbal memory deficits are particularly relevant in early-onset schizophrenia.
  • Neuropsychological assessments and remediation strategies should prioritize verbal memory in these patients.