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A novel immunomodulator, FTY720, prevents spontaneous dermatitis in NC/Nga mice
Takeyuki Kohno1, Takumi Tsuji, Kaori Hirayama
1Department of Environmental Health Sciences, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan. kohno@pharm.setsunan.ac.jp
Biological & Pharmaceutical Bulletin
|September 2, 2004
Abstract:
Oral administration of a novel immunomodulator, FTY720 (0.1 mg/kg, once a week), completely prevented the spontaneous development of dermatitis in NC/Nga mice. It also strongly suppressed hyper IgE production in serum, as well as hypertrophy of the epidermis and the degranulation of granulocytes in the skin, all of which were observed in mice in which the dermatitis had become established. These results strongly suggest that FTY720 is a promising candidate for treatment of human atopic dermatitis.