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In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
08:13

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

Published on: February 16, 2016

[Quantitative myocardial perfusion assessment with magnetic resonance imaging in patients with coronary artery

V V Gramovich1, V E Sinitsyn, M P Gordin

  • 1Cardiology Research Complex; ul. Tretiya Cherepkovskaya, 15a, 121552 Moscow, Russia; N. Bauman Moscow Technical University.

Kardiologiia
|September 2, 2004
PubMed

Insights

Quantifying myocardial blood flow (MBF) and myocardial blood flow reserve (MBFR) using MRI is feasible in coronary artery disease (CAD) patients. This technique accurately detects CAD and assesses treatment effectiveness post-revascularization.

Area of Science:

  • Cardiovascular Imaging
  • Medical Physics
  • Radiology

Background:

  • Coronary artery disease (CAD) diagnosis relies on invasive methods.
  • Non-invasive quantification of myocardial perfusion is crucial for assessing CAD severity and treatment response.

Purpose of the Study:

  • To evaluate the feasibility of quantifying absolute myocardial blood flow (MBF), total coronary resistance (TCR), and myocardial blood flow reserve (MBFR) using MRI.
  • To assess the diagnostic accuracy of MBFR in detecting significant coronary stenoses.
  • To determine the utility of MRI-derived perfusion parameters before and after revascularization.

Main Methods:

  • 19 CAD patients and 9 healthy subjects underwent first-pass contrast perfusion MRI at rest and during pharmacologic hyperemia (dipyridamole).
  • Signal intensity curves from myocardial segments and left ventricle cavity were analyzed using a one-compartment model and slope-method.
  • Gd-DTPA-BMA concentration was derived from signal intensity using an in vitro calibration curve.

Main Results:

  • MBFR was significantly lower in patients with significant CAD (stenosis >/=50%) compared to those with non-significant stenosis or normal arteries.
  • MBFR cutoff value of
  • Post-revascularization, MBF increased, TCR decreased, and MBFR normalized in treated myocardial segments.

Conclusions:

  • Absolute MBF and MBFR quantification using first-pass contrast perfusion MRI is feasible in CAD patients.
  • MRI-derived MBFR is a valuable tool for detecting significant coronary artery stenoses.
  • Perfusion MRI effectively assesses hemodynamic changes before and after revascularization procedures.
Abstract

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