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Related Experiment Videos

Pharmacogenomics: bench to bedside.

Richard Weinshilboum1, Liewei Wang

  • 1Mayo Medical School-Mayo Graduate School, Mayo Clinic College of Medicine, Department of Molecular Pharmacology and Experimental Therapeutics, Rochester, Minnesota 55905, USA. weinshilboum.richard@mayo.edu

Nature Reviews. Drug Discovery
|September 2, 2004
PubMed
Summary
This summary is machine-generated.

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Pharmacogenetics and pharmacogenomics study how genes affect drug responses to personalize medicine. Research is advancing to translate these genetic insights into clinical practice for better patient outcomes.

Area of Science:

  • Pharmacogenomics
  • Genetics
  • Clinical Pharmacology

Background:

  • Pharmacogenetics investigates genetic influences on individual drug responses.
  • The goal is to optimize drug efficacy and reduce toxicity through personalized therapy.
  • Advances in genomics have propelled pharmacogenetics into pharmacogenomics.

Purpose of the Study:

  • To summarize the evolution of pharmacogenetics into pharmacogenomics.
  • To discuss factors influencing the clinical translation of pharmacogenomics.
  • To highlight challenges in implementing pharmacogenomics at the bedside.

Main Methods:

  • Literature review and synthesis of historical development.
  • Analysis of key factors impacting clinical translation.

Related Experiment Videos

  • Identification of challenges for bench-to-bedside implementation.

    • Main Results:

    • Pharmacogenetics has evolved into pharmacogenomics.
    • Several factors influence the translation of pharmacogenomics into clinical practice.
    • Significant challenges remain in achieving widespread clinical adoption.

    Conclusions:

    • The translation of pharmacogenomics holds promise for personalized medicine.
    • Addressing identified challenges is crucial for successful clinical implementation.
    • Continued research and collaboration are needed to bridge the gap between research and practice.