Nanosuspensions in drug delivery.

Area of Science:

• Pharmaceutical Sciences
• Drug Delivery
• Nanotechnology

Background:

• A significant number of novel drug candidates exhibit poor water solubility.
• This poor solubility often leads to low bioavailability and development failure.
• Such compounds are often termed 'brickdust' candidates.

Purpose of the Study:

• To address the challenge of poor water solubility in new drug candidates.
• To explore the potential of crystalline nanosuspensions for drug formulation.
• To highlight the pharmacokinetic benefits of nanosuspension technology.

Main Methods:

• Formulation of insoluble drug candidates into crystalline nanosuspensions.
• Characterization of nanosuspension properties.
• Evaluation of bioavailability and pharmacokinetic profiles.

Main Results:

• Crystalline nanosuspensions successfully rescued poorly soluble 'brickdust' drug candidates.
• Improved solubility and bioavailability were achieved through nanosuspension formulation.
• Additional pharmacokinetic advantages were observed with this formulation approach.

Conclusions:

• Nanosuspension technology offers a viable solution for developing water-insoluble drugs.
• Overcoming solubility limitations has led to a paradigm shift in drug development.
• This approach enables the advancement of innovative future therapeutics.