Maiming mitochondria in familial ALS

PARP1 deficiency mitigates amyloid pathology, neurodegeneration, and cognitive decline in a familial Alzheimer's disease model.

Proceedings of the National Academy of Sciences of the United States of America·2026

Protocols for Assessing the Nuclease Activity of MIF.

Methods in molecular biology (Clifton, N.J.)·2026

MIF Tautomerase Inhibition Protects Neurons From Immune-Mediated Cell Death.

Neurology(R) neuroimmunology & neuroinflammation·2026

Gut-initiated alpha synuclein fibrils drive parkinsonism phenotypes: temporal mapping of REM sleep behavior disorder-like and other non-motor symptoms.

Translational neurodegeneration·2026

Autoimmune neuroinflammation leads to neuronal death via MIF nuclease-mediated parthanatos.

Nature neuroscience·2026

Mapping cellular vulnerability in Parkinson's disease using retro-AAVs and preformed α-synuclein fibrils.

Translational neurodegeneration·2026

Immunotherapy with a short-lived anti-PD-L1 antibody in Alzheimer's disease: a phase 1b, randomized, double-blind trial.

Nature medicine·2026

Oligonucleotide-siRNA conjugate for SOD1 amyotrophic lateral sclerosis: a phase 1 trial.

Nature medicine·2026

An anti-PMEL antibody-drug conjugate with a Gq/11 inhibitor payload in GNAQ/GNA11-mutant melanomas: a phase 1 trial.

Nature medicine·2026

Anti-LAG-3 with or without anti-PD-1 in recurrent glioblastoma: a phase 1 trial.

Nature medicine·2026

Health system learning enables generalist neuroimaging models.

Nature medicine·2026

KRAS-G12D inhibitor HRS-4642 plus chemotherapy in advanced KRASG12D-mutant pancreatic cancer: a phase 1b/2 trial.

Nature medicine·2026

Ketosis elevates plasma concentrations of D-β-hydroxybutyryl-phenylalanine (BHB-Phe) in humans.

Nutrition & metabolism·2026

Disruption of Branched-chain Amino Acids Homeostasis Exacerbates MCD-induced Steatohepatitis by Amplifying a Pro-inflammatory Positive Feedback Loop between Hepatocytes and Macrophages.

The Journal of nutritional biochemistry·2026

Ketogenic β-hydroxybutyrate-regulated β-hydroxybutyrylation of HSPE1 alleviates neuronal apoptosis in MPTP/MPP+ induced Parkinson's disease models.

Food & function·2026

The Role of Urea Cycle Functional Studies in Preclinical Research.

Journal of inherited metabolic disease·2026

Targeted liquid chromatography-tandem mass spectrometry profiling of arginine and histidine derivatives in chronic migraine: Discriminatory performance and changes after onabotulinumtoxinA therapy.

Headache·2026

Percent body fat misclassifies patients with sarcopenia as obese: support for fat mass index in obesity assessment.

Journal of the Endocrine Society·2026

Related Experiment Videos

Maiming mitochondria in familial ALS

Related Concept Videos

PARP1 deficiency mitigates amyloid pathology, neurodegeneration, and cognitive decline in a familial Alzheimer's disease model.

Protocols for Assessing the Nuclease Activity of MIF.

MIF Tautomerase Inhibition Protects Neurons From Immune-Mediated Cell Death.

Gut-initiated alpha synuclein fibrils drive parkinsonism phenotypes: temporal mapping of REM sleep behavior disorder-like and other non-motor symptoms.

Autoimmune neuroinflammation leads to neuronal death via MIF nuclease-mediated parthanatos.

Mapping cellular vulnerability in Parkinson's disease using retro-AAVs and preformed α-synuclein fibrils.

Immunotherapy with a short-lived anti-PD-L1 antibody in Alzheimer's disease: a phase 1b, randomized, double-blind trial.

Oligonucleotide-siRNA conjugate for SOD1 amyotrophic lateral sclerosis: a phase 1 trial.

An anti-PMEL antibody-drug conjugate with a G<sub>q/1</sub><sub>1</sub> inhibitor payload in GNAQ/GNA11-mutant melanomas: a phase 1 trial.

Anti-LAG-3 with or without anti-PD-1 in recurrent glioblastoma: a phase 1 trial.

Health system learning enables generalist neuroimaging models.

KRAS-G12D inhibitor HRS-4642 plus chemotherapy in advanced KRAS<sup>G12D</sup>-mutant pancreatic cancer: a phase 1b/2 trial.

Ketosis elevates plasma concentrations of D-β-hydroxybutyryl-phenylalanine (BHB-Phe) in humans.

Disruption of Branched-chain Amino Acids Homeostasis Exacerbates MCD-induced Steatohepatitis by Amplifying a Pro-inflammatory Positive Feedback Loop between Hepatocytes and Macrophages.

Ketogenic β-hydroxybutyrate-regulated β-hydroxybutyrylation of HSPE1 alleviates neuronal apoptosis in MPTP/MPP<sup>+</sup> induced Parkinson's disease models.

The Role of Urea Cycle Functional Studies in Preclinical Research.

Targeted liquid chromatography-tandem mass spectrometry profiling of arginine and histidine derivatives in chronic migraine: Discriminatory performance and changes after onabotulinumtoxinA therapy.

Percent body fat misclassifies patients with sarcopenia as obese: support for fat mass index in obesity assessment.

Related Experiment Videos

Maiming mitochondria in familial ALS

Related Concept Videos

Related Articles