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[Hemorheologic changes in patients with liver diseases].
Kai Wang1, Dong-sheng Wang, Xiao-peng Fan
1Department of Infectious Liver Diseases of Qilu Hospital, Shandong University, Jinan 250012, China.
Summary
Hemorheology and microcirculation are altered in liver diseases like hepatitis B and TTV infection. Blood viscosity changes indicate disease severity, suggesting hemorheology as a diagnostic marker.
Area of Science:
- Hematology
- Hepatology
- Virology
Context:
- Liver diseases, including hepatitis B and TTV infection, can impact systemic circulation.
- Understanding hemorheological changes is crucial for assessing disease progression and microcirculatory disturbances.
Purpose:
- To investigate variations in hemorheology and microcirculation across different stages of liver disease.
- To analyze the correlation between viral load (HBV DNA, TTV DNA) and hemorheological parameters.
Summary:
- Significant alterations in blood viscosity (BV), red blood cell (RBC) aggregation, and hematocrit (HCT) were observed in patients with hepatitis B and TTV infections compared to controls.
- Compensated cirrhosis showed highly viscous blood, while decompensated cirrhosis exhibited low viscosity.
- No correlation was found between HBV DNA levels and hemorheological indices, but TTV infection was associated with increased blood viscosity.
Impact:
- Microcirculatory disturbances are evident in patients with hepatitis B or TTV infection.
- Hemorheological parameters offer potential as supplementary markers for liver disease detection alongside traditional HBV markers.
- TTV infection may contribute to adverse hemorheological effects.