Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[AGE-RAGE: a hypothesis or a mechanism?].

Berend Isermann1, Angelika Bierhaus, Per M Humpert

  • 1Abteilung Endokrinologie und Stoffwechsel, Universitätsklinik Heidelberg, Heidelberg. berend.isermann@med.uni-heidelberg.de

Herz
|September 2, 2004
PubMed
Summary

Hyperglycemia accelerates atherosclerosis through advanced glycation endproducts (AGEs) interacting with the Receptor for AGEs (RAGE). This interaction promotes inflammation and oxidative stress, contributing to cardiovascular disease in diabetes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Placental plasminogen activator inhibitor 1 is induced by platelet-derived TGF-β independently of TGF-β receptor 3 and is upregulated in preeclampsia.

Molecular human reproduction·2026
Same author

Prioritizing Conservation of Trailing-Edge Populations for Future Climate-Resilient Forests.

Global change biology·2026
Same author

Effect of green mediterranean diet on serum folate and its interaction with genetic variation in folate metabolism: The DIRECT PLUS 18-month dietary randomized controlled trial.

Clinical nutrition (Edinburgh, Scotland)·2026
Same author

Lifestyle-Induced Visceral Fat Loss as a Key Target for Durable Cardiometabolic Health: MRI-Assessed 5- and 10-Year Follow-Up After 2 Clinical Trials.

Circulation·2026
Same author

Endothelial dysfunction and metabolic biomarkers in post-COVID-19 syndrome.

Scientific reports·2026
Same author

Obesity-Related Coagulation Activation in Adolescents and Children: A Systematic Review and Meta-Analysis.

Obesity reviews : an official journal of the International Association for the Study of Obesity·2026

Area of Science:

  • Cardiovascular Science
  • Endocrinology
  • Molecular Biology

Background:

  • Hyperglycemia in diabetes is linked to accelerated atherosclerosis.
  • The AGE-RAGE pathway is a proposed mechanism for this accelerated atherosclerosis.

Purpose of the Study:

  • To explore the role of advanced glycation endproducts (AGEs) and their receptor (RAGE) in the pathogenesis of accelerated atherosclerosis.
  • To investigate the molecular mechanisms linking hyperglycemia, AGE-RAGE interaction, and cardiovascular complications in diabetes.

Main Methods:

  • Review of existing literature and recent experimental data on AGE-RAGE interactions.
  • Analysis of in vivo studies demonstrating the role of ligand-RAGE interaction in diabetes-related atherosclerosis.
  • Examination of data from diabetic patient atherosclerotic lesions.

Related Experiment Videos

Main Results:

  • Hyperglycemia promotes AGE formation, which interacts with RAGE.
  • Ligand-RAGE interaction activates NF-kappaB, leading to cytokine release, inflammation, and oxidative stress.
  • In vivo and human studies support the pathogenetic role of RAGE-ligand interactions in diabetic atherosclerosis.

Conclusions:

  • The AGE-RAGE interaction is a significant pathway contributing to accelerated atherosclerosis in diabetes.
  • Further research is needed to fully characterize the diverse ligand-RAGE interactions and develop targeted therapies.