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[Insulin therapy improves cardiac autonomic function in type 2 diabetic patients]
Oliver Schnell1, Sonja Kilinc, Aurel Rambeck
13. Medizinische Abteilung KH München-Schwabing und Institut für Diabetesforschung, München. OliverSchnell@lrz.uni-muenchen.de
Herz
|September 2, 2004
Summary
Insulin therapy significantly improved cardiac autonomic function in type 2 diabetes patients. Cardiac reflex tests are valuable for monitoring autonomic function during diabetes treatment.
Area of Science:
- Cardiology
- Endocrinology
- Diabetology
Background:
- Diabetic patients often experience cardiac autonomic dysfunction.
- Insulin therapy may improve cardiac autonomic innervation in diabetes.
Purpose of the Study:
- To evaluate the impact of insulin therapy on cardiac autonomic function in type 2 diabetes mellitus.
- To assess changes in cardiac reflex test parameters following insulin treatment.
Main Methods:
- 30 type 2 diabetes patients with HbA1c > 7.5% initiated insulin therapy.
- Cardiac autonomic function assessed using five cardiac reflex tests and QTc-interval.
- Follow-up duration was 4 months.
Main Results:
- Insulin therapy led to a significant decrease in HbA1c from 9.2% to 7.2%.
- Three cardiac autonomic function parameters (CV of HRV at rest, CV of HRV during deep breathing, 30:15 ratio) showed significant improvement.
- QTc-interval duration significantly decreased from 417 ms to 398 ms.
Conclusions:
- Insulin therapy optimizes cardiac autonomic function in type 2 diabetes.
- Cardiac reflex tests are effective for monitoring autonomic function in diabetic patients undergoing insulin treatment.