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Repeated gamma knife radiosurgery for multiple metastatic brain tumours
1Department of Neurosurgery, Yokohama Rosai Hospital, 3211 Kozukue-cho, Koukoku-ku, Yokohama, Kanagawa 222-0036, Japan. shuto@yokohamah.rofuku.go.jp
Acta Neurochirurgica
|September 2, 2004
Summary
Repeated gamma knife radiosurgery (GKS) effectively treats multiple brain metastases, offering relatively long survival for some patients with minimal radiation injury risk.
Area of Science:
- Neurosurgery
- Radiation Oncology
- Oncology
Background:
- Evaluating the efficacy of repeated gamma knife radiosurgery (GKS) for multiple brain metastases.
- Assessing treatment outcomes in patients undergoing multiple GKS procedures.
Purpose of the Study:
- To determine the effectiveness of repeat gamma knife radiosurgery (GKS) in managing multiple brain metastases.
- To analyze survival rates and patient outcomes following multiple GKS treatments.
Main Methods:
- Study included 16 patients (10 men, 6 women; mean age 60.3 years) with 242 tumors who underwent GKS four or more times.
- Total of 83 GKS procedures performed (mean 5.2 per patient) for newly developed metastatic tumors.
- Analyzed tumor progression, survival time, Karnofsky performance status, and radiation-induced injury.
Main Results:
- Median survival was 22.4 months; primary tumor site and adjuvant whole brain radiation did not significantly affect survival.
- Karnofsky performance status decreased significantly from initial to final GKS.
- Only about 30% of patients died due to brain lesion progression, irrespective of multiple metastases.
Conclusions:
- Repeated gamma knife radiosurgery (GKS) is an effective treatment for brain metastases.
- Patients may experience relatively long survival with a low risk of radiation-induced injury.
- GKS offers a viable option for managing recurrent or multiple brain metastases.