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Related Experiment Videos

Obsessive-compulsive disorder after unilateral caudate nucleus bleeding.

S Thobois1, E Jouanneau, M Bouvard

  • 1Service de Neurologie D, Hôpital Neurologique et Neurochirurgical Pierre Wertheimer, Lyon, France.

Acta Neurochirurgica
|September 2, 2004
PubMed
Summary

Obsessive compulsive disorder (OCD) can occur after basal ganglia lesions. This case highlights a unilateral lesion causing pure compulsive behavior, suggesting a frontal deafferentation mechanism.

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Area of Science:

  • Neuroscience
  • Neurology
  • Psychiatry

Background:

  • Basal ganglia lesions, often bilateral, are associated with obsessive compulsive disorders (OCD).
  • The pathophysiology linking basal ganglia damage to OCD symptoms is not fully understood.
  • Previous research suggests a connection between basal ganglia lesions and OCD development.

Observation:

  • A 24-year-old man presented with pure compulsive behavior.
  • The patient had a unilateral hemorrhage in the left caudate nucleus caused by a cavernoma.
  • This unilateral lesion is atypical compared to previously reported cases.

Findings:

  • The unilateral caudate nucleus hemorrhage led to a specific compulsive behavioral disorder.
  • This case suggests that even unilateral basal ganglia lesions can trigger OCD symptoms.

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  • The observed pathophysiology points towards a frontal cortex deafferentation mechanism.

    • Implications:

    • This case expands the understanding of OCD's neurological underpinnings.
    • It highlights the potential for unilateral lesions to cause complex behavioral changes.
    • Further investigation into the efficacy of treatments for secondary OCD is warranted.