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Updated: Aug 22, 2026

Minimally Invasive Cisterna Magna Injection Model for Leptomeningeal Metastasis Studies in Mice
Published on: May 23, 2025
Pure distant, leptomeningeal metastasis of esthesioneuro-epithelioma
J Bogucki1, A Taraszewska, Z Czernicki
1Department of Neurosurgery, Medical Research Centre, Polish Academy of Sciences, Cegłowska St. 80, 01-809 Warsaw, Poland. neuropan@cmdik.pan.pl
Background:
Esthesioneuro-epithelioma is a very rare variant of olfactory neuroblastoma that originates in the region of the cribriform plate. Its intracranial manifestation is due to infiltration of the anterior skull base and frontal lobes.
Methods:
The authors describe a 52-year-old man with a history of a subtotally resected right maxillary sinus ethesioneuro-epithelioma 2 years earlier who presented with a left hemiparesis and signs of increased intracranial pressure. CT examination revealed a tumour of the right temporoparietal region. The tumour and its dural attachment were totally removed. The patient made a full recovery postoperatively.
Findings:
The features of esthesioneuro-epithelioma were found on histopathological examination.
Interpretation:
The intracranial tumour resected was a distant, leptomeningeal metastasis of esthesioneuro-epithelioma. To our knowledge such a documented case has not been published before.
