[Determination of the severity of endogenous intoxication at the level of average molecular peptides]

A possibility was demonstrated of using the method related with determination of the level of average-weight molecules or average molecules (AM) for the diagnosis of sudden death in forensic medical expertise of cadaver. Blood plasma was investigated according to the method of M.I. Gabriekyan modified by Yu. V. Pervushin, which involves deproteinization of samples with subsequent spectrophotometry at 254 and 280 nm. The AM levels were studied in different pathologies including cardiovascular diseases, alcoholic and narcotic intoxications and pneumonia, caused by a variety of agents, as well as the syndrome of sudden children's death. An analysis of the obtained results denotes a possibility of using the postmortem determination of the AM level concurrently with determination of an endogenous intoxication degree in the forensic medical practice for establishing the cause and mechanisms of nonviolent death.