Regional therapy of liver metastases

Liver metastases usually represent disseminated cancer; therefore, systemic chemotherapy is always appropriate. However, in some instances, the liver is the only site of metastasis and regional control of liver tumors may have important palliative and survival benefits, including a possibility of cure in selected patients. This review identifies unique patient subgroups that may benefit from regional therapy of liver metastases, and considers different treatment options and when these different options may be indicated.