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Does ondansetron attenuate amphetamine-induced behaviour in human volunteers?
P H Silverstone1, B Johnson, P J Cowen
1Psychopharmacology Research Unit, Littlemore Hospital, Oxford, UK.
Psychopharmacology
|January 1, 1992
Summary
Ondansetron, a 5-HT3 receptor antagonist, significantly reduced amphetamine-induced hunger suppression in male volunteers. This suggests ondansetron may modulate amphetamine
Area of Science:
- Pharmacology
- Neuroscience
- Human Physiology
Background:
- Amphetamine is known to decrease hunger.
- The 5-HT3 receptor antagonist ondansetron's role in modulating amphetamine's effects is not fully understood.
- Animal studies suggest ondansetron can affect catecholamine-mediated behaviors.
Purpose of the Study:
- To investigate the effect of ondansetron on amphetamine-induced reduction in hunger.
- To explore the interaction between 5-HT3 receptors and amphetamine's appetite-suppressing properties in humans.
Main Methods:
- A double-blind, cross-over study design was employed.
- Nine healthy male volunteers participated in the study.
- Participants received either amphetamine alone or amphetamine pre-treated with ondansetron.
Main Results:
- Amphetamine (15 mg) significantly decreased self-reported hunger 2.5 hours post-administration.
- Pre-treatment with ondansetron (12 mg) significantly attenuated this hunger-decreasing effect of amphetamine.
- The findings align with animal data on ondansetron's modulation of amphetamine's catecholamine-related behaviors.
Conclusions:
- Ondansetron attenuates the hunger-reducing effects of amphetamine in humans.
- This suggests a potential role for 5-HT3 receptors in mediating amphetamine's impact on appetite.
- Pharmacokinetic interactions between ondansetron and amphetamine require further investigation.