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Synthesis of dimeric acridine derived antivirals
René Csuk1, Alexander Barthel, Torsten Brezesinski
1Institut f. Organ. Chemie, Martin-Luther-Universität Halle-Wittenberg, Kurt-Mothes-Str. 2, D-06120 Halle (Saale), Germany. csuk@chemie.uni-halle.de
Bioorganic & Medicinal Chemistry Letters
|September 3, 2004
Abstract:
A series of antiviral compounds consisting of an intercalating acridine derived part, a spacer region and a reactive EDTA derived conjugate was synthesized in an easy sequence starting from 1,omega-alkyldiamines. As shown in model screenings, in the presence of ascorbic acid the Fe-complexes of these compounds reduced the phage-titer of MS2-phages by >8 logarithmic decades.