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Biological effects of induction immunosuppression.
1National Institute of Diabetes and Digestive and Kidney Diseases, Room 11S219, Building 10, 10 Center Drive, Bethesda, Maryland 20892, USA. douglash@intra.niddk.nih.gov
Current Opinion in Immunology
|September 3, 2004
Summary
Induction immunosuppression strategies are advancing beyond lymphocyte depletion. Modern approaches utilize non-depletional effects and target antigen-presenting cells for safer, more effective immunosuppression.
Area of Science:
- Immunology
- Transplantation Medicine
Background:
- Induction immunosuppression historically compensated for less effective maintenance regimens.
- Current strategies aim to reduce maintenance immunosuppression dosages through advanced induction protocols.
Purpose of the Study:
- To explore the evolving concept of induction immunosuppression.
- To highlight the shift from lymphocyte depletion to broader non-depletional mechanisms.
- To discuss the potential of targeting antigen-presenting cells and regulatory factors.
Main Methods:
- Review of current literature on induction immunosuppression agents and mechanisms.
- Analysis of non-depletional effects beyond lymphocyte depletion.
- Examination of emerging research on antigen-presenting cell and regulatory factor modulation.
Main Results:
- Induction immunosuppression now enables reduced maintenance drug dosages.
- Non-depletional effects, including receptor modulation and blockade, are key to efficacy.
- Focus is expanding to include antigen-presenting cells and regulatory factors.
Conclusions:
- Induction immunosuppression is a dynamic field with evolving strategies.
- Modern induction therapies offer a more refined approach to immunosuppression.
- Future directions emphasize safety and efficacy through novel mechanisms.