Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Increased CXCL8 (IL-8) expression in Multiple Sclerosis.

Brett T Lund1, Nazely Ashikian, Huy Q Ta

  • 1Department of Neurology, Keck School of Medicine, University of Southern California, MCH-142, Los Angeles, California 90033, USA. blund@usc.edu

Journal of Neuroimmunology
|September 3, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Targeting Vascular TRPV4 Activity Prevents Lung Transplant Ischemia-Reperfusion Injury and Rejection.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2026
Same author

Considering Pregnancy: Duality in the Reproductive Journey and Decision-Making in Hispanic Women With Systemic Lupus Erythematosus in the United States.

ACR open rheumatology·2026
Same author

New biological agents in systemic lupus erythematosus.

Expert opinion on biological therapy·2026
Same author

Late-Onset Rheumatoid Arthritis and Air Pollution in a Multiethnic Cohort.

Arthritis & rheumatology (Hoboken, N.J.)·2026
Same author

Rheumatic Immune-Related Adverse Events: Immune Checkpoint Inhibitor Therapy and Ramifications for Health Disparities.

Cureus·2025
Same author

Sex-Associated Disparities in Industry Payments to US Authors in High-Impact Rheumatology Journals: Correlation with Author Impact.

ACR open rheumatology·2025

Chemokine CXCL8 (also known as Interleukin-8) levels are elevated in untreated Multiple Sclerosis (MS) patients, suggesting its role in monocyte recruitment to the central nervous system.

Area of Science:

  • Neuroimmunology
  • Inflammatory Diseases
  • Cellular Biology

Background:

  • Multiple Sclerosis (MS) is a chronic central nervous system (CNS) inflammatory disease.
  • MS pathology involves mononuclear cell infiltration and demyelination.
  • CXCL8 (Interleukin-8) is a chemokine that attracts neutrophils and monocytes, promoting endothelial adhesion.

Purpose of the Study:

  • To investigate the role of CXCL8 in Multiple Sclerosis.
  • To assess CXCL8 serum levels and peripheral blood mononuclear cell (PBMC) secretion in MS patients.
  • To evaluate the impact of interferon-beta1a therapy on CXCL8 levels.

Main Methods:

  • Measurement of serum CXCL8 levels in untreated MS patients and controls.
  • Assessment of CXCL8 secretion from PBMCs in MS patients and controls.

Related Experiment Videos

  • Comparison of CXCL8 levels before and after interferon-beta1a therapy in MS patients.

    • Main Results:

    • Serum CXCL8 levels were significantly higher in untreated MS patients compared to controls.
    • PBMCs from untreated MS patients showed significantly higher CXCL8 secretion than controls.
    • Interferon-beta1a therapy significantly reduced serum CXCL8 levels and PBMC secretion in MS patients.

    Conclusions:

    • CXCL8 may serve as a biomarker for monocyte activity in Multiple Sclerosis.
    • CXCL8 likely contributes to monocyte recruitment into the CNS in MS.
    • CXCL8 levels may be modulated by interferon-beta1a treatment in MS.