Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Recurrent sites for new centromere seeding.

Mario Ventura1, Stefania Weigl, Lucia Carbone

  • 1Sezione di Genetica-Dipartimento di Anatomia Patologica e Genetica, University of Bari, 70126 Bari, Italy.

Genome Research
|September 3, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

KMT2A and KMT2B episignatures address diagnostic challenges associated with rare neurodevelopmental disorders.

Genetics in medicine : official journal of the American College of Medical Genetics·2026
Same author

Dystrophia Smolandiensis is characterized by a novel NQO1 variant and a distinct phenotype from COL17A1-associated epithelial recurrent erosion dystrophy.

Acta ophthalmologica·2026
Same author

A Homozygous Deep Intronic SNX14 Variant Activates Pseudo-Exon Inclusion in a Patient with SCAR20.

Genes·2026
Same author

The genomic medicine center Karolinska 10-year report on genome sequencing for rare diseases and a strategy for stepwise clinical implementation.

Genome medicine·2026
Same author

First Reported Use of Recombinant Parathyroid Hormone in Kenny-Caffey Syndrome Type 2: A Case Report and Literature Review.

Diseases (Basel, Switzerland)·2026
Same author

Bi-allelic ATG12 variants impair autophagy and cause a neurodevelopmental disorder.

American journal of human genetics·2026

Human chromosome evolution reveals latent centromere regions prone to reactivation. These findings suggest a shared mechanism for neocentromere formation in humans and evolutionary centromere emergence.

Area of Science:

  • Genetics
  • Evolutionary Biology
  • Genomics

Background:

  • Comparative genomic hybridization (FISH) and genomic analyses were employed to investigate chromosome 3 evolution in primates.
  • The study focused on two cases of human neocentromeres on the long arm of chromosome 3.

Observation:

  • One human neocentromere case (3q26) coincided with a region where a new centromere arose in Old World monkey ancestors (25-40 million years ago).
  • Another centromere emergence in great ape ancestors was orthologous to a site in New World monkey ancestors.
  • A second human neocentromere case (3q24) occurred without typical chromosomal rearrangements, involving normal centromere inactivation in a phenotypically normal individual.

Findings:

  • The research indicates recurrent activation of dormant centromere regions, highlighting their inherent potential for centromere formation.

Related Experiment Videos

  • The second human neocentromere case demonstrated a novel mechanism involving functional inactivation of the primary centromere.
  • This unusual chromosome was successfully transmitted to offspring, indicating stability.

    • Implications:

    • The findings suggest a conserved mechanism underlying both human neocentromere formation and evolutionary centromere emergence.
    • This implies that specific chromosomal regions possess a latent capacity to form functional centromeres.
    • Understanding these mechanisms could offer insights into chromosomal instability and evolution.