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Extensive genomic polymorphism within Mycobacterium avium.

Makeda Semret1, Gary Zhai, Serge Mostowy

  • 1McGill University Health Center, Montreal, Quebec, Canada.

Journal of Bacteriology
|September 3, 2004
PubMed
Summary
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Comparative genomics revealed 14 large sequence polymorphisms (LSPs) distinguishing Mycobacterium avium subspecies. A key finding includes a mycobactin biosynthesis gene variation potentially explaining paratuberculosis dependence.

Area of Science:

  • Microbiology
  • Genomics
  • Bacterial Pathogenesis

Background:

  • Mycobacterium avium comprises distinct subspecies, including M. avium subsp. avium and M. avium subsp. paratuberculosis.
  • Understanding genomic differences is crucial for differentiating these subspecies and their associated diseases.

Purpose of the Study:

  • To perform a comparative genomic analysis of Mycobacterium avium subspecies.
  • To identify genetic variations that distinguish M. avium subsp. avium from M. avium subsp. paratuberculosis.

Main Methods:

  • Comparative genomic analysis using DNA microarray technology.
  • Identification and characterization of large sequence polymorphisms (LSPs).

Main Results:

  • Discovered 14 large sequence polymorphisms (LSPs) spanning over 700 kb differentiating the subspecies.

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  • Genes involved in metabolic pathways were found to be overrepresented within these LSPs.
  • Identified a specific polymorphism in the mycobactin biosynthesis operon.

    • Conclusions:

    • The identified LSPs provide key genomic markers for distinguishing M. avium subsp. avium and M. avium subsp. paratuberculosis.
    • The polymorphism in mycobactin biosynthesis may explain the observed in vitro mycobactin dependence of M. avium subsp. paratuberculosis.