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Intussusception in early childhood: a cohort study of 1.7 million children
Thea Kølsen Fischer1, Kristine Bihrmann, Michael Perch
1Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd, MS-A34, Atlanta, GA 30333, USA. thf7@cdc.gov
Insights
Intussusception incidence in Danish children remained stable until 1990, then significantly decreased by 55% through 2001. This decline was most notable in infants aged 3 to 5 months, indicating a positive public health trend.
Area of Science:
- Pediatric epidemiology
- Gastrointestinal health
Background:
- Intussusception is a serious gastrointestinal condition in infants and young children.
- Understanding incidence trends is crucial for public health monitoring and resource allocation.
Purpose of the Study:
- To analyze the incidence and temporal trends of intussusception in Danish children.
- To investigate changes in intussusception rates between 1980 and 2001.
Main Methods:
- Population-based cohort study in Denmark (1980-2001).
- Involved 1.67 million children younger than 5 years.
- Utilized the Danish National Patient Registry to identify cases and calculate age-specific incidence rates.
Main Results:
- 1814 cases of intussusception were reported.
- Incidence was stable from 1980-1990.
- A 55% decrease in incidence was observed from 1990-2001, most significant in 3-5 month olds.
Conclusions:
- Intussusception incidence in Danish children declined significantly in the 1990s.
- The reduction was particularly pronounced in infants aged 3 to 5 months.
Objective:
To describe incidence and temporal trends of intussusceptions in Danish children during 1980 to 2001.
Methods:
A population-based cohort study was conducted of 1.67 million children who were younger than 5 years during 1980 to 2001 and were followed up for 6.66 million person-years. The Danish National Patient Registry was used to identify cases of intussusception in the cohort. Age-specific incidence rates were main outcome measure.
Results:
A total of 1814 cases of intussusception among children who were younger than 5 years were reported from 1980 to 2001. The incidence rate remained fairly constant during 1980 to 1990 but decreased by 55% (95% confidence interval: 43%-65%) from 1990 to 2001. The reduction was most pronounced among children aged 3 to 5 months.
Conclusions:
The incidence of intussusception among Danish children declined significantly during the 1990s, particularly among infants 3 to 5 months of age.
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