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Updated: Jul 21, 2026

Imaging of HIV-1 Envelope-induced Virological Synapse and Signaling on Synthetic Lipid Bilayers
Published on: March 8, 2012
Dangerous liaisons at the virological synapse
Vincent Piguet1, Quentin Sattentau
1Department of Dermatology and Venereology, University Hospital of Geneva, Geneva, Switzerland. vincent.piguet@medecine.unige.ch
Abstract:
Cell-to-cell viral transmission facilitates the propagation of HIV-1 and human T cell leukemia virus type 1. Mechanisms of cell-to-cell transmission by retroviruses were not well understood until the recent description of virological synapses (VSs). VSs function as specialized sites of immune cell-to-cell contact that direct virus infection. Deciphering the molecular mechanisms of VS formation provides a fascinating insight into how pathogens subvert immune cell communication programs and achieve viral spread.
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