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Updated: Aug 22, 2026

Surgical Models of Gastroesophageal Reflux with Mice
Published on: August 25, 2015
[Pro-inflammatory chemokine IL-8 in gastroesophageal reflux disease]
Yuji Naito1, Norimasa Yoshida, Toshikazu Yoshikawa
1Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine.
Abstract:
Recent reports have demonstrated significantly higher expression levels of interleukin-8 (IL-8) in patients with gastroesophageal reflux disease (GERD) including non-erosive reflux disease (NERD). The levels of IL-8 mRNA expression were significantly decreased after proton pump inhibitor. The esophageal expression of CINCs, rat IL-8-like chemokines, was markedly enhanced in the models of acute or chronic esophagitis in rats. The production of IL-8 from esophageal mucosal cells was enhanced by the exposure to bile acid. These results suggest that IL-8 chemokine may play a major role in the pathogenesis of esophageal inflammation in GERD.
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