Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Primary care for GEDR].

Hiroshi Takeda1

  • 1Department of Internal Medicine 3, Hokkaido University Hospital.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|September 4, 2004
PubMed
Summary
This summary is machine-generated.

Proton pump inhibitors (PPIs) are more effective than H2 receptor antagonists (H2RAs) for treating gastroesophageal reflux disease (GERD). Refractory GERD may be linked to nocturnal acid breakthrough, suggesting

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Congenital Kir6.2 deficiency, but not acute K<sub>ATP</sub> channel blockade, attenuates apomorphine-induced locomotor activity in mice.

Pharmacology, biochemistry, and behavior·2026
Same author

SirT2 Inhibition is Associated with Improvements in Depression-like Behavior and Memory Impairment in Olfactory Bulbectomized Mice.

Molecular neurobiology·2026
Same author

AICAR improves depression-like behaviors and is associated with hippocampal AMPK activation and modulation of neurogenesis and neuroinflammation in a microbiota disruption model.

Neurochemistry international·2026
Same author

Effects of sacubitril/valsartan according to daily salt intake and comparison with thiazide add-on treatment in patients with uncontrolled hypertension.

Hypertension research : official journal of the Japanese Society of Hypertension·2025
Same author

Comparison of renal effects between sacubitril/valsartan and thiazide diuretics among patients with uncontrolled hypertension and chronic kidney disease in Japan.

Clinical and experimental nephrology·2025
Same author

Neuronal dysfunction in the amygdala is involved in anxiety-like behaviors accompanying ulcerative colitis.

Neuroscience letters·2025

Area of Science:

  • Gastroenterology
  • Pharmacology

Background:

  • Gastroesophageal reflux disease (GERD) management focuses on reducing gastric acid.
  • Proton pump inhibitors (PPIs) and H2 receptor antagonists (H2RAs) are primary medical treatments.

Purpose of the Study:

  • To review current treatment approaches for GERD.
  • To evaluate the efficacy of different GERD treatment strategies.

Main Methods:

  • Review of current medical literature on GERD treatment.
  • Comparison of PPIs and H2RAs for healing and symptom relief.
  • Analysis of treatment approaches: 'step up' vs. 'step down' therapy.

Main Results:

  • PPIs demonstrate superior efficacy over H2RAs in healing erosive esophagitis and relieving GERD symptoms.

Related Experiment Videos

  • A subset of GERD patients exhibit refractory symptoms despite PPI treatment.
  • Nocturnal acid breakthrough is identified as a potential cause of refractory GERD.

    • Conclusions:

    • PPIs are the preferred initial pharmacotherapy for GERD due to faster healing and symptom resolution.
    • 'Step down' therapy is currently favored over 'step up' for initial GERD management.
    • Further investigation into nocturnal acid breakthrough is warranted for refractory GERD cases.