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Updated: Aug 22, 2026

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
Published on: May 14, 2013
Drug-eluting stents: caution and concerns for long-term outcome
Renu Virmani1, Andrew Farb, Giulio Guagliumi
1Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC, USA. virmani@afip.osd.mil
Abstract:
Recent publications on drug-eluting stents (DES) report a significant reduction in restenosis rates as compared to bare metal stents in patients mostly with single vessel disease. We have recently observed however, late stent thrombosis following CYPHER DES implantation. The patient developed a hypersensitivity reaction around stent struts limited to the polymer with aneurysmal dilatation and extensive inflammation of the arterial wall in the absence of vascular healing. This incidence promotes a cautionary view and perhaps supports the use of DES only in high-risk patients.
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