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Updated: Aug 8, 2026

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms
08:46

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms

Published on: December 9, 2015

Aspirin resistance: current concepts

Peter J Mason1, Jane E Freedman, Alice K Jacobs

  • 1Section of Cardiology, Boston University Medical Center, Boston, Massachusetts, USA.

Reviews in Cardiovascular Medicine
|September 4, 2004
PubMed

Insights

Aspirin resistance, the failure of aspirin to prevent cardiovascular events, affects 5% to 45% of people. Understanding its mechanisms and detection is crucial for improving patient outcomes.

Area of Science:

  • Cardiology
  • Pharmacology
  • Thrombosis

Background:

  • Aspirin is a key antiplatelet medication for preventing cardiovascular events.
  • Variable individual responses to aspirin therapy contribute to persistent risks of recurrent vascular events.
  • Aspirin resistance is a recognized phenomenon, though formal diagnostic criteria are absent.

Purpose of the Study:

  • To review the biological mechanisms of aspirin resistance.
  • To discuss the prevalence of aspirin resistance in the general population.
  • To explore laboratory methods for detecting aspirin resistance and its clinical significance.

Main Methods:

  • Literature review of studies on aspirin's antiplatelet effects.
  • Analysis of data on aspirin resistance prevalence and variability.
  • Examination of diagnostic approaches and clinical implications.

Main Results:

  • Individual variability in aspirin's antithrombotic effects is significant.
  • Aspirin resistance occurs in a substantial portion of the population (5%–45%).
  • Detection of aspirin resistance holds potential clinical importance for treatment optimization.

Conclusions:

  • Aspirin resistance can explain the high rate of recurrent vascular events in some patients.
  • Further research into mechanisms, detection, and clinical relevance is warranted.
  • Identifying aspirin resistance may lead to personalized antiplatelet strategies.

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