Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Photoremovable protecting groups based on electron transfer chemistry.

Daniel E Falvey1, Chitra Sundararajan

  • 1Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA.

Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology
|September 4, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Selective photo labeling of tryptophan in N-acetyl-L-tryptophan ethyl ester and peptide WWCNDGR with a diaryl nitrenium ion.

Photochemistry and photobiology·2026
Same author

Identifying efficiency-loss pathways in triplet-triplet annihilation upconversion systems.

Physical chemistry chemical physics : PCCP·2025
Same author

Rearrangement, Elimination, and Ring-Opening Reactions of Cyclopropyl-Substituted Nitrenium Ions: A Computational and Experimental Investigation.

The Journal of organic chemistry·2024
Same author

Lamp vs Laser: A Visible Light Photoinitiator That Promotes Radical Polymerization at Low Intensities and Cationic Polymerization at High Intensities.

The Journal of organic chemistry·2023
Same author

Photochemical generation and characterization of the 5-endo-10,11-dihydrodibenzoazepine nitrenium ion.

Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology·2022
Same author

Elucidating complex triplet-state dynamics in the model system isopropylthioxanthone.

iScience·2022
Same journal

Exploring the structural, morphological and optical properties of iron based metalloporphyrin in the nano regime for biomedical applications.

Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology·2026
Same journal

Emission-tunable aromatic thiadiazole derivatives based on triphenylimidazole with aggregation-induced emission activity and their application in osteosarcoma imaging.

Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology·2026
Same journal

40th anniversary of the European Society for photobiology : History and scientific significance.

Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology·2026
Same journal

NO-PDT and chemotherapy: spatiotemporal control to achieve therapeutic synergy.

Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology·2026
Same journal

Synthesis of tetrazole based donor-acceptor type fluorescent molecules and their interaction with transport protein bovine serum albumin.

Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology·2026
Same journal

Rational design of an S-scheme 2D/3D ZnIn<sub>2</sub>S<sub>4</sub>/K<sub>3</sub>PW<sub>12</sub>O<sub>40</sub> heterojunction for enhanced photocatalytic antibiotic degradation.

Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology·2026
See all related articles

Photoremovable protecting groups (PRPGs) use light to control chemical reactions, enabling precise spatial and temporal release of active molecules. Recent advances focus on photoinduced electron transfer for enhanced control over light wavelengths used in the release process.

Area of Science:

  • Organic Chemistry
  • Photochemistry
  • Chemical Biology

Background:

  • Photoremovable protecting groups (PRPGs) temporarily inactivate molecules, releasing them upon light exposure.
  • PRPGs offer precise spatial and temporal control in chemical reactions.
  • Applications include physiological studies and DNA library fabrication.

Purpose of the Study:

  • To explore novel PRPGs utilizing photoinduced electron transfer (PET).
  • To enable controlled photochemical release of various functional groups.
  • To offer greater control over light wavelengths for PRPG uncaging.

Main Methods:

  • Design and synthesis of new PRPGs based on PET mechanisms.
  • Photochemical studies to assess release kinetics and efficiency.

Related Experiment Videos

  • Demonstration of PRPG application for amine, alcohol, ketone, and carboxylic acid release.

    • Main Results:

    • Successful development of PRPGs activated by PET.
    • Demonstrated precise control over the release of protected molecules.
    • Broad applicability shown for various functional groups.

    Conclusions:

    • PET-based PRPGs provide advanced control over photochemical release.
    • These PRPGs are versatile tools for chemical and biological applications.
    • The strategy allows for decoupling light absorption from bond cleavage.