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Heat stability of a recombinant DNA hepatitis B vaccine
P Van Damme1, M Cramm, A Safary
1University of Antwerp, Department of Epidemiology and Community Medicine, Belgium.
Vaccine
|January 1, 1992
Abstract:
The heat stability of a recombinant DNA hepatitis B vaccine was studied in healthy adult volunteers. When compared with vaccine stored at 4 degrees C, heating of the vaccine for 1 week at 45 degrees C or for 1 month at 37 degrees C did not alter the reactogenicity or the ability of the vaccine to elicit antibody titres considered to be protective. These results have significance in situations where the cold chain is broken, as can happen in countries where proper storage and transport facilities are not always available.