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Updated: Aug 22, 2026

Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus
Published on: December 5, 2015
Changes in the size of maternal inferior vena cava during pregnancy
Eiji Ryo1, Nobuya Unno, Tsuneki Nagasaka
1Department of Obstetrics and Gynecology, Musashino Red Cross Hospital, Tokyo, Japan. yonchi@med.teikyo-u.ac.jp
Aims:
To investigate the changes in the size of maternal inferior vena cava (IVC) during normal pregnancy.
Methods:
The diameter and the area of IVC were measured in 32 non-pregnant and 214 pregnant women by ultrasonography. They were measured not only in the supine but also in the complete left lateral position when gestation was over 16 weeks.
Results:
IVC in the 4-7 weeks pregnant group was larger than that in the non-pregnant group, and it decreased as gestation progressed during an early stage of pregnancy. After 16 weeks gestation, it demonstrated no change, at least for depending on the periods when the mother was in the supine position. On the contrary, they increased with the gestational progress as for the maternal left lateral position.
Conclusions:
The size of IVC at an early stage of pregnancy is enlarged, suggesting an underfilling state of arterial circulation. In the second and third trimesters, it is stationary when the mother is supine. In the left lateral position, it increases as the gestation progresses, reflecting blood volume expansion during pregnancy.
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