Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Parkinson's disease--new horizons].

K Bötzel1

  • 1Neurologische Klinik der Ludwig-Maximilians-Universität München, Klinikum Grosshadern. Kai.Boetzel@med.uni-muenchen.de

MMW Fortschritte Der Medizin
|September 7, 2004
PubMed
Summary

New insights into Parkinson's disease pathology and genetics reveal protein distribution patterns that indicate disease stage. Future treatments will focus on neuroprotection and neurorestoration to slow disease progression.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Parasomnia and paroxysmal dyskinesia].

Der Nervenarzt·2017
Same author

Anticipatory postural adjustments are unaffected by age and are not absent in patients with the freezing of gait phenomenon.

Experimental brain research·2016
Same author

Normative data for arm swing asymmetry: how (a)symmetrical are we?

Gait & posture·2014
Same author

Intermediate latency evoked potentials of cortical multimodal vestibular areas: acoustic stimulation.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2014
Same author

Limited cleavage of tau with matrix-metalloproteinase MMP-9, but not MMP-3, enhances tau oligomer formation.

Experimental neurology·2012
Same author

[Deep brain stimulation in Parkinson's disease: overview on the pros and cons of an effective therapy].

Fortschritte der Neurologie-Psychiatrie·2011

Area of Science:

  • Neuroscience
  • Genetics
  • Pathology

Context:

  • Parkinson's disease (PD) is a progressive neurodegenerative disorder.
  • Current treatments primarily manage symptoms.
  • Understanding the underlying pathology is crucial for developing disease-modifying therapies.

Purpose:

  • To explore novel therapeutic targets for Parkinson's disease.
  • To investigate the role of protein misfolding and genetic mutations in PD.
  • To outline future treatment strategies beyond symptom control.

Summary:

  • Recent findings highlight the significance of pathologically folded proteins in Parkinson's disease.
  • The distribution of these proteins in the brain correlates with disease staging.
  • Genetic mutations in familial cases offer further insights into disease mechanisms.

Impact:

  • Advances in understanding Parkinson's disease pathology and genetics.
  • Opens new avenues for developing neuroprotective and neurorestorative treatments.
  • Informs the development of first-line treatments like dopamine agonists for younger patients.

Related Experiment Videos