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Updated: Aug 22, 2026

Quantification of Mouse Heart Left Ventricular Function, Myocardial Strain, and Hemodynamic Forces by Cardiovascular Magnetic Resonance Imaging
Published on: May 24, 2021
Single and biplane TrueFISP cardiovascular magnetic resonance for rapid evaluation of left ventricular volumes and
Burkhard Sievers1, Bodo Brandts, Ulrich Franken
1Department of Cardiology and Angiology, University of Bochum, Herne, Germany. burkhard.sievers@gmx.de
Introduction:
Cardiovascular magnetic resonance (CMR) allows very accurate, but time-consuming, volume assessment by the short-axis slice summation technique. The single and biplane methods of volume assessment are used less, partly because FLASH cine imaging provides poor blood-myocardium contrast in long-axis views. TrueFISP gives excellent blood-myocardium contrast, even in patients with heart failure. We hypothesized that the single plane and biplane methods of volume assessment in TrueFISP images might provide an acceptable degree of accuracy and be quicker than the short axis method, and that single and biplane left ventricular volume assessment would be more accurate with TrueFISP than with FLASH in patients with impaired ventricular function.
Methods:
Short- and long-axis CMR images were obtained by FLASH and TrueFISP with a 1.5-T scanner. We determined the accuracy of both single and biplane long-axis methods for left ventricular volume and ejection fraction (EF) measurements compared with the conventional short-axis method in 10 heart failure patients using both FLASH and TrueFISP and in 9 healthy subjects using TrueFISP.
Results:
No difference in volumes and EF was found between the single plane method, the biplane method, and the short-axis method using TrueFISP for image acquisition, in both patients and healthy subjects. The same was true of the results obtained by FLASH in the patients with heart failure.
Conclusions:
The single and biplane methods, regardless of whether TrueFISP or FLASH is used, are a reasonable and rapid alternative to the conventional short-axis approach for left ventricular volume and EF assessment in patients with heart failure and impaired ventricular function.
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