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Epidemiological, clinical and allergological observations on pompholyx
1Clinica Dermatologica, Università di Milano, Ospedale San Paolo, Italy.
Contact Dermatitis
|January 1, 1992
Summary
Pompholyx (dyshidrosis) is linked to allergies, particularly nickel. Many patients have atopic diathesis and elevated IgE, with nickel allergy being common. Environmental factors also play a role.
Area of Science:
- Dermatology
- Allergology
- Immunology
Background:
- Pompholyx, also known as dyshidrosis, is a skin condition of unknown cause.
- Previous studies suggest various allergological factors may be involved, but their role remains unclear.
Purpose of the Study:
- To investigate the relationship between allergological factors and the etiopathogenesis of pompholyx.
- To identify potential allergens and aggravating factors contributing to pompholyx development.
Main Methods:
- A study of 104 pompholyx patients and 208 controls.
- Evaluated blood IgE levels, patch, prick, intradermal, and oral provocation tests (nickel sulfate).
- Assessed familial/personal atopic diathesis and aggravating factors like season and hyperhidrosis.
Main Results:
- 50% of patients had atopic diathesis vs. 11.5% of controls (p<0.001).
- 37.49% of patients had high IgE levels.
- Nickel sulfate showed highest patch test positivity (20.19% vs. 6.25%, p<0.001), with 26% overall allergic to nickel.
- Season and hyperhidrosis were common aggravating factors.
Conclusions:
- Allergological factors, especially nickel allergy and atopic diathesis, are significantly associated with pompholyx.
- Multiple allergens or antigens may trigger pompholyx in predisposed individuals.
- Further research is needed to fully elucidate the role of these factors in pompholyx pathogenesis.