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Updated: Aug 22, 2026
In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
Published on: February 16, 2016
Impact of patient motion on myocardial perfusion SPECT diagnostic integrity: Part 2
Janelle M Wheat1, Geoffrey M Currie
1School of Clinical Sciences, Charles Sturt University, Wagga Wagga, New South Wales, Australia. jwheat@csu.edu.au
Objective:
Advances in 99mTc-based radiopharmaceuticals and multiple-detector gantries have the potential to increase the significance of patient motion on the diagnostic integrity of myocardial perfusion SPECT acquisitions.
Methods:
An experimental study was used to evaluate the effect of various patient motions on the diagnostic integrity of myocardial perfusion SPECT data using 522 motion simulations generated from a technically and diagnostically normal dataset.
Results:
Of studies with induced motion, 21.7% of simulated motion demonstrated motion-induced artifacts. Abrupt motion resulted in artifacts for 52.6% of studies, whereas bounce motion resulted in artifacts in 6.8% of studies. The locations where motion resulted in the most studies with artifacts were at 45 degrees (36.1%) and 75 degrees (32.4%). No statistical difference was demonstrated between single, dual-, and triple-head configurations.
Conclusion:
Combining these results with those of the clinical evaluation of incidence indicates that patient motion during 99mTc-based myocardial perfusion SPECT studies is a potential source of false-positive findings for coronary artery disease. There is a 7.1% probability that myocardial perfusion SPECT studies performed at the 3 sites investigated will contain a motion-induced artifact. Fully realized, this potential results in decreased test specificity and unfavorable cost and consequence outcomes.
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