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Spectrum of atypical celiac disease in North Indian children

Amrinder Singh Puri1, Sanjay Garg, Rajnish Monga

  • 1Department of Gastroenterology, GB Pant Hospital, New Delhi, India. amarpuri_286@msn.com

Indian Pediatrics
|September 7, 2004
PubMed

Insights

Atypical celiac disease (ACD) in Indian children often presents subtly, with short stature or anemia, not just diarrhea. Early diagnosis is crucial as osteoporosis is common in these cases.

Area of Science:

  • Pediatric Gastroenterology
  • Clinical Immunology
  • Endocrinology

Background:

  • Atypical celiac disease (ACD) presentation in childhood is underreported in India.
  • Standard diagnostic criteria (ESPGHAN) were used.
  • ACD may present without typical gastrointestinal symptoms.

Purpose of the Study:

  • To analyze the clinical features of children with atypical celiac disease in India.
  • To compare ACD cases with typical diarrheal celiac disease (CD).

Main Methods:

  • Retrospective analysis of pediatric CD cases over 5 years.
  • Comparison of biochemical and hematological parameters between ACD and typical CD groups.
  • Bone mineral densitometry (BMD) was performed in selected ACD patients.

Main Results:

  • Seven out of twelve diagnosed CD patients presented with ACD.
  • No significant differences in age, hematological, or biochemical profiles between ACD and typical CD.
  • Osteoporosis was prevalent in all evaluated ACD patients (6/6).
  • Short stature and refractory iron deficiency anemia were the most common ACD presentations.

Conclusions:

  • Atypical celiac disease presentation in Indian children is characterized by short stature and refractory iron deficiency anemia.
  • The presence of these conditions warrants investigation for celiac disease.
  • Early diagnosis and management of ACD are essential to prevent complications like osteoporosis.

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