Chemical micropatterning of polymeric cell culture substrates using low-pressure hydrogen gas discharge plasmas

Micropatterned cell cultures will allow a new quality of bioartificial systems. Here, an approach to chemical micropatterning of polymer substrates is presented, which is completely based on low pressure gas discharge processes. Well expressed micropatterned cell cultures on polystyrene and poly (ether ether ketone) were obtained with many different cell types. No impairment of typical cell behavior was observed.