Jove
Visualize
Contact Us

Related Experiment Videos

Functionalized copolymers and their composites with polylactide and hydroxyapatite.

S Jin1, K E Gonsalves

  • 1Department of Chemistry & Polymer Program at the Institute of Materials Science, University of Connecticut, Storrs, CT 06269, USA.

Journal of Materials Science. Materials in Medicine
|September 7, 2004
PubMed
Summary

New copolymers, poly(epsilon-caprolactone-co-vinylphosphonic acid) and poly(epsilon-caprolactone-co-dimethylvinylphosphoester), enhance polylactide composites. These materials facilitate hydroxyapatite deposition, improving composite properties for potential biomedical applications.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Measurement of the prompt <i>J</i>/[Formula: see text] pair production cross-section in <i>pp</i> collisions at [Formula: see text] TeV with the ATLAS detector.

The European physical journal. C, Particles and fields·2017
Same author

The performance of the jet trigger for the ATLAS detector during 2011 data taking.

The European physical journal. C, Particles and fields·2017
Same author

Search for new phenomena in different-flavour high-mass dilepton final states in <i>pp</i> collisions at [Formula: see text] Tev with the ATLAS detector.

The European physical journal. C, Particles and fields·2017
Same author

Search for bottom squark pair production in proton-proton collisions at [Formula: see text] TeV with the ATLAS detector.

The European physical journal. C, Particles and fields·2017
Same author

Search for gluinos in events with an isolated lepton, jets and missing transverse momentum at [Formula: see text] = 13 Te V with the ATLAS detector.

The European physical journal. C, Particles and fields·2017
Same author

Performance of pile-up mitigation techniques for jets in [Formula: see text] collisions at [Formula: see text] TeV using the ATLAS detector.

The European physical journal. C, Particles and fields·2017
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Area of Science:

  • Materials Science
  • Biomaterials Engineering
  • Polymer Chemistry

Background:

  • Developing advanced biomaterials is crucial for tissue engineering and regenerative medicine.
  • Polylactide (PLac) is a widely used biodegradable polymer, but its properties can be limited for certain applications.
  • Hydroxyapatite (HAp) is a key component of bone, making it desirable for bone regeneration scaffolds.

Purpose of the Study:

  • To synthesize and characterize novel copolymers for composite material development.
  • To investigate the ability of these copolymers to promote hydroxyapatite nucleation and growth.
  • To create advanced organic-inorganic composites with enhanced properties.

Main Methods:

  • Synthesis of poly(epsilon-caprolactone-co-vinylphosphonic acid) (P(MDOVPA)) and poly(epsilon-caprolactone-co-dimethylvinylphosphoester) (P(MDOVPE)).

Related Experiment Videos

  • Preparation of composites using P(MDOVPA) as a filler in polylactide (PLac) films.
  • Characterization of hydroxyapatite (HAp) growth using Fourier transform infrared spectroscopy (FTIR), energy dispersive X-ray analysis (EDX), and X-ray diffraction (XRD).
  • Blending of P(MDOVPE) with PLac to form miscible blends and subsequent creation of multilayered composites with HAp.

    • Main Results:

    • P(MDOVPA) demonstrated pendant functional groups P(O)(OH)2, acting as effective nucleation sites for HAp deposition in simulated body fluid.
    • HAp growth was successfully observed and confirmed on both P(MDOVPA) powder and PLac-P(MDOVPA) films.
    • The incorporation of hydrophilic P(MDOVPA) into PLac significantly increased the hydrophilicity of the resulting blend.
    • Miscible blends of P(MDOVPE) and PLac were formed, enabling the creation of porous structures for composite fabrication.

    Conclusions:

    • Synthetic copolymers P(MDOVPA) and P(MDOVPE) are effective in modifying the properties of polylactide.
    • P(MDOVPA) facilitates controlled hydroxyapatite mineralization, suggesting potential for bone tissue engineering applications.
    • The developed composite materials offer a promising platform for advanced biomaterial design.