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Related Experiment Videos

Novel reverse thermoresponsive injectable poly(ether carbonate)s.

Daniel Cohn1, Alejandro Sosnik

  • 1Casali Institute of Applied Chemistry, The Hebrew University of Jerusalem, 91904 Jerusalem, Israel. danielc@vms.huji.ac.il

Journal of Materials Science. Materials in Medicine
|September 7, 2004
PubMed
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This study introduces novel poly(ether carbonate) block copolymers that exhibit enhanced reverse thermal gelation (RTG) properties. These new materials offer significantly improved viscosity and stability compared to existing PEO-PPO-PEO triblocks for thermoreversible applications.

Area of Science:

  • Polymer Science
  • Materials Science
  • Rheology

Background:

  • Polymers exhibiting reverse thermal gelation (RTG) show increased viscosity with rising temperature.
  • Existing poly(ethylene oxide)/poly(propylene oxide)/poly(ethylene oxide) (PEO-PPO-PEO) triblock copolymers have limited viscosity increase and stability.

Purpose of the Study:

  • To develop and characterize a new family of reverse thermoresponsive alternating [A-B](n) block copolymers.
  • To investigate the impact of compositional and structural parameters on gelation concentration (Ci) and temperature (Ti).
  • To evaluate the rheological properties of these novel copolymers in aqueous solutions.

Main Methods:

  • Synthesis of alternating PEO-PPO block copolymers using phosgene.
  • Characterization using Gel Permeation Chromatography (GPC), NMR, FT-IR, and Differential Scanning Calorimetry (DSC).

Related Experiment Videos

  • Rheological analysis using a Brookfield viscometer; solution behavior studied by Dynamic Light Scattering (DLS) and fluorescence spectroscopy.

    • Main Results:

    • The novel poly(ether carbonate) copolymers demonstrated significantly superior rheological properties compared to PEO-PPO-PEO triblocks.
    • A 15% aqueous solution of the developed copolymers achieved viscosities between 25,000 and 150,000 Pa.s at 37°C.
    • This represents a substantial improvement over Pluronic F-127, which reached only 5,000 Pa.s under similar conditions.

    Conclusions:

    • The newly synthesized poly(ether carbonate) block copolymers offer enhanced RTG performance.
    • These materials present a promising alternative for applications requiring thermoreversible hydrogels with high viscosity and stability.