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Related Experiment Videos

Biocompatibility of solid poly (ortho ester).

M Ekholm1, A Salo, S Syrjänen

  • 1Department of Maxillofacial Surgery, Helsinki University Central Hospital, Finland.

Journal of Materials Science. Materials in Medicine
|May 1, 1997
PubMed
Summary
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Solid poly (ortho ester) (POE) induced moderate inflammation in rabbit tibiae for 9 weeks. Gamma-sterilized POE resorbed by 7 weeks, while ethylene oxide-sterilized POE resorbed by 13 weeks.

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Orthopedic Surgery

Background:

  • Poly (ortho ester) (POE) shows potential as a resorbable device, hemostatic sealant, and drug carrier in bone surgery.
  • Understanding the tissue response to implanted POE is crucial for its clinical application.

Purpose of the Study:

  • To evaluate the tissue reactions and resorption characteristics of solid poly (ortho ester) implants in rabbit tibiae.
  • To compare the effects of different sterilization methods (gamma radiation vs. ethylene oxide) on POE resorption and tissue response.

Main Methods:

  • Solid POE rods were implanted into the tibiae of 17 rabbits.
  • Histological examination of bony specimens and immunohistochemical analysis of connective tissue were performed at follow-up times from 1 to 21 weeks.

Related Experiment Videos

  • Tenascin and fibronectin expression was assessed to study extracellular matrix glycoprotein presence.

    • Main Results:

    • Solid POE induced a moderate inflammatory reaction lasting up to 9 weeks post-implantation.
    • Tenascin and fibronectin were detected in the tissue samples between 1 and 4 weeks.
    • Gamma-sterilized POE demonstrated resorption by 7 weeks, whereas ethylene oxide-sterilized POE was resorbed by 13 weeks.

    Conclusions:

    • Solid poly (ortho ester) elicits a moderate, transient inflammatory response in bone tissue.
    • The sterilization method significantly impacts the resorption rate of POE implants.
    • These findings provide valuable insights into the biocompatibility and degradation of POE for orthopedic applications.