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Related Experiment Videos

Resorbable continuous-fibre reinforced polymers for osteosynthesis.

M Dauner1, H Planck, L Caramaro

  • 1Institut für Textil- und Verfahrenstechnik (ITV), Koerschtalstrasse 26, D-73770 Denkendorf, Germany.

Journal of Materials Science. Materials in Medicine
|September 7, 2004
PubMed
Summary

Researchers developed resorbable osteosynthesis devices using continuous-fibre reinforced poly-L-lactide. While biocompatible, fast degradation due to residual monomers requires further investigation for clinical use.

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Area of Science:

  • Biomaterials Engineering
  • Polymer Science
  • Orthopedic Surgery

Background:

  • Development of resorbable osteosynthesis devices is crucial for improved patient outcomes.
  • Continuous-fibre reinforcement offers potential for enhanced mechanical properties.

Purpose of the Study:

  • To develop processing technologies for continuous-fibre reinforced resorbable osteosynthesis devices.
  • To synthesize and characterize poly-L-lactide (P-L-LA) and poly-L-DL-lactide (P-L-DL-LA) for device fabrication.
  • To evaluate the in vitro and in vivo performance of the developed devices.

Main Methods:

  • Melt-spun P-L-LA fibres (800 MPa) embedded in amorphous P-L-DL-LA 70:30 matrix via compression moulding.
  • Ethylene oxide sterilization of samples.

Related Experiment Videos

  • In vitro and in vivo testing, including non-functional animal studies in rabbits.

    • Main Results:

    • Achieved a satisfying bending modulus of 6 GPa.
    • Observed 50% strength retention after ten weeks.
    • Demonstrated fast degradation, leading to 70% resorption after one year in rabbit studies.
    • Confirmed good biocompatibility with only mild inflammatory reactions during resorption.

    Conclusions:

    • The developed processing method allows for fibre orientation, a key advantage for osteosynthesis devices.
    • Fast degradation, potentially linked to residual monomers, necessitates further research.
    • Future efforts should focus on reducing initial monomer content for controlled resorption.